Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Breast anticancer drug tamoxifen and its metabolites bind DNA and RNA at multiple sites

Breast anticancer drug tamoxifen and its metabolites bind DNA and RNA at multiple sites

Tajmir-Riahi, Heidar-Ali

Paperback

Chemistry

Currently unavailable to order

ISBN10: 3330873930
ISBN13: 9783330873933
Publisher: Ed Universitaires Europeennes
Published: May 31 2017
Pages: 84
Weight: 0.30
Height: 0.20 Width: 6.00 Depth: 9.00
Language: English
Tamoxifen is a breast anticancer drug that has been in worldwide use for the treatment of estrogen receptor (ER)-positive breast cancer for over 30 years. We compare the binding sites of the tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen with DNA and tRNA. Structural models showed that tamoxifen and its metabolites bind DNA and tRNA at multiple sites via hydrophobic, hydrophilic and H-bonding contacts with tRNA forming more stable drug conjugates than DNA. Drug conjugation did not alter DNA and tRNA conformations, while major biopolymer aggregation occurred at high drug contents. The drug loading efficacy is correlated with the mechanism of action of antitumor activity of tamoxifen and its metabolites.

Also in

Chemistry

View All