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Allostery: Methods and Protocols
Hardcover
Series: Methods in Molecular Biology, Book 796
Medical ReferenceBiologyChemistry
ISBN13: 9781617793332
Publisher: Humana
Published: Nov 4 2011
Pages: 439
Weight: 2.22
Height: 1.00 Width: 7.00 Depth: 10.00
Language: English
Part I: Monitoring Allosteric Function
1. Binding Techniques to Study the Allosteric Energy Cycle
James K. Kranz and Jose C. Clemente
2. Kinetic Trapping of a Key Hemoglobin Intermediate
Jo M. Holt and Gary K. Ackers
3. Allosteric Coupling Between Transition Metal Binding Sites in Homooligomeric Metal Sensor Proteins
Nicholas E. Grossoehme and David P. Giedroc
4. Studying the Allosteric Energy Cycle by Isothermal Titration Calorimetry
Marta Martinez-Julvez, Olga Abian, Sonia Vega, Milagros Medina, and Adrian Velazquez-Campoy
5. Detecting Silent Allosteric Coupling
Harvey F. Fisher
6. Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors
Jai A.P. Shanata, Shawnalea J. Frazier, Henry A. Lester, and Dennis A. Dougherty
Part II: Monitoring Allosteric Conformational Changes
7. A Review of Methods Used for Identifying Structural Changes in a Large Protein Complex
Owen W. Nadeau and Gerald M. Carlson
8. Allosteric Mechanisms of G Protein-Coupled Receptor Signaling: A Structural Perspective
Tarjani M. Thaker, Ali I. Kaya, Anita M. Preininger, Heidi E. Hamm, and T.M. Iverson
9. Dynamic Light Scattering to Study Allosteric Regulation
Aaron L. Lucius, P. Keith Veronese, and Ryan P. Stafford
10. Dissecting the Linkage Between Transcription Factor Self-Assembly and Site-Specific DNA Binding: The Role of the Analytical Ultracentrifuge
Amie D. Moody, James P. Robblee, and David L. Bain
11. Fluorescence Correlation Spectroscopy and Allostery: The Case of GroEL
Gabriel A. Frank, Amnon Horovitz, and Gilad Haran
12. The Morpheein Model of Allostery: Evaluating Proteins as Potential Morpheeins
Eileen K. Jaffe and Sarah H. Lawrence
Part III: Monitoring Allosteric Changes in Protein Dynamics/Sub-Population Distribution
13. Combining NMR and Molecular Dynamics Studies for Insights into the Allostery of Small GTPase-Protein Interactions
Liqun Zhang, Sabine Bouguet-Bonnet, and Matthias Buck
14. H/D-Exchange Study of an Allosteric Energy Cycle
Dorothy Beckett
15. Ensemble Properties of Network Rigidity Reveal Allosteric Mechanisms
Donald J. Jacobs, Dennis R. Livesay, James M. Mottonen, Oleg K. Vorov, Andrei Y. Istomin, and Deeptak Verma
Part IV: Macromolecular and Ligand Engineering Allosteric Functions
16. An In Vivo Approach to Isolating Allosteric Pathways Using Hybrid Multimeric Proteins
Cuijuan Tie and Gregory D. Reinhart
17. Mutations in the GABAA Receptor that Mimic the Allosteric Ligand, Etomidate
Stuart A. Forman and Deirdre Stewart
18. Allosteric Regulation of Human Liver Pyruvate Kinase by Peptides that Mimic the Phosphorylated/Dephosphorylated N-Terminus
Charulata B. Prasannan, Qingling Tang, and Aron W. Fenton
19. In Silico Screening Approaches for Lead Generation: Identification of Novel Allosteric Modulators of Human-Erythrocyte Pyruvate Kinase
Ashutosh Tripathi and Martin K. Safo
20. Identification of Allosteric-Activating Drug Leads for Human Liver Pyruvate Kinase
Aron W. Fenton
Part V: Computation
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