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Active Site-Directed Enzyme Inhibitors: Design Concepts

Active Site-Directed Enzyme Inhibitors: Design Concepts

Hardcover

BiologyChemistry

ISBN10: 1839161973
ISBN13: 9781839161971
Publisher: Royal Society of Chemistry
Published: Sep 13 2023
Pages: 200
Weight: 1.05
Height: 0.70 Width: 6.20 Depth: 9.30
Language: English

Our biological system is enriched with enzyme-catalyzed (or enzymatic) reactions that mediate a great multitude of life processes such as gene transcription and metabolism, and the inappropriately up-regulated activity of these enzymatic reactions is a major cause of human diseases such as cancer and metabolic diseases. Therefore, the inhibitors of enzymatic reactions (generally called enzyme inhibitors) constitute a major class of therapeutic agents on the global drug market. One question would then be how to efficiently design enzyme inhibitors. This handbook is the first of its kind in the field, introducing to its readers in a single book the concepts whose exploitation has been demonstrated to be successful in efficiently furnishing effective active site-directed inhibitors for various enzymatic reactions.

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Chemistry