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Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis
Hardcover
Medical ReferenceSports GeneralChemistry
ISBN13: 9789811374494
Publisher: Springer Nature
Published: Nov 26 2019
Pages: 101
Weight: 0.75
Height: 0.31 Width: 6.14 Depth: 9.21
Language: English
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
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