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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Application of the radioisotope ²²⁵Ac in medicinal chemistry

Application of the radioisotope ²²⁵Ac in medicinal chemistry

Ferreira de Souza, Andréa Luzia
Machado, Arthur de Assis

Paperback

Chemistry

ISBN10: 6207823605
ISBN13: 9786207823604
Publisher: Our Knowledge Publishing
Published: May 27 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: English
The paper describes an introduction to alpha particles and their importance. As well as applications of the radionuclide Ac in the field of medicinal chemistry in the period between the years 2022-2024. The paper's introduction tells a little about the history of the discovery and importance of radiochemical elements. As well as the conceptualization of alpha, beta and gamma particles. In medicinal chemistry, cancer can be treated by exposing cancer cells to radiation (alpha, beta or gamma). Alpha radiation, as described in targeted alpha therapy, usually delivers directly to the cancer cells, killing the cancer cells without also damaging nearby healthy tissue. The Ac-225 isotope has a half-life of 10 days, long enough to incorporate it into a radiopharmaceutical that has time to circulate in the body but short enough for it to decay to stable products without adverse dose consequences. This paper describes a brief bibliographical review of the application of the radionuclide Ac-225 in the field of medicinal chemistry, covering the topics of chelating agents used in the treatment of tumors, some nanoparticles and, finally, radiopharmaceuticals.

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