Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
1,3,4-Oxadiazole: Synthesis of Derivatives with Antioxidant & Enzyme Inhibition Activities

1,3,4-Oxadiazole: Synthesis of Derivatives with Antioxidant & Enzyme Inhibition Activities

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General Science

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ISBN10: 9384097012
ISBN13: 9789384097011
Publisher: Pharmamedix India Publication Pvt. Ltd.
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: English
Oxadiazole is bioactive class of compounds and its derivatives are used widely in drugs and for the treatment of many diseases like neuro-disorders, muscle disorders etc. In the undertaken research work, a series of S-substituted derivatives of 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-thiol (6a-l) were synthesized in various steps. Organic acid 4-nitrobenzoic acid (1) was successfully converted into ester and consequently into its hydrazide in the presence of hydrazine hydrated and methanol as a solvent. Further, 4-nitrobenzoic acid hydrazide (3) yielded 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-thiol, on treatment with carbon disulfide in the presence of base (KOH) and ethanol. Finally the target compounds (6a-l) were obtained by stirring 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-thiol with different electrophiles (5a-l) in the presence of sodium hydride (NaH) and dimethyl formamide (DMF). All these derivatives along with their parent compounds were characterized by IR, EI-MS and 1H-NMR.

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