The Gene That Cracked the Cancer Code
1st Edition Hardcover ISBN: 1472910516
All of us have lurking in our DNA a most remarkable gene. Its job is straightforward – to protect us from cancer. This gene – known simply as p53 – constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA as part of its process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged and malfunctioning. Not surprisingly, p53 is the most studied gene in history. Sue Armstrong's p53: The Gene That Cracked the Cancer Code is the story of the quest to unravel the mysteries of p53 and to get at the heart of what happens in our cells when they turn cancerous. Discovered in 1979, most notably by David Lane at the Imperial Cancer Research Fund in London and Arnie Levine at Princeton University, p53 has teased the minds of some of the most colorful and ambitious scientists around the world. As the twenty-first century revolution in personalized cancer treatments finally has started to take off, p53 is at the forefront of the hunt for new cures. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
A Brief History of Everyone Who Ever Lived
The Human Story Retold Through Our Genes
Paperback ISBN: 1615194940
In our unique genomes, every one of us carries the story of our species—births, deaths, disease, war, famine, migration, and a lot of sex. But those stories have always been locked away—until now. Who are our ancestors? Where did they come from? Geneticists have suddenly become historians, and the hard evidence in our DNA has blown the lid off what we thought we knew. Acclaimed science writer Adam Rutherford explains exactly how genomics is completely rewriting the human story—from 100,000 years ago to the present. A Brief History of Everyone Who Ever Lived will upend your thinking on Neanderthals, evolution, royalty, race, and even redheads. (For example, we now know that at least four human species once roamed the earth.) Plus, here is the remarkable, controversial story of how our genes made their way to the Americas—one that’s still being written, as ever more of us have our DNA sequenced. Rutherford closes with “A Short Introduction to the Future of Humankind,” filled with provocative questions that we’re on the cusp of answering: Are we still in the grasp of natural selection? Are we evolving for better or worse? And . . . where do we go from here?
The Cosmic Serpent
Dna and the Origins of Knowledge
Trade Paperback ISBN: 075380851X
First published in 1998, this is an adventure in science and imagination. Narby researched the Peruvian Indians' claim that their phenomenal knowledge of plants and biochemical interactions was communicated to them directly whilst under the influence of the plant-derived hallucinogen and concludes that those claims are literally true.
Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
Hardcover ISBN: 0804140138
"The authors of the New York Times bestseller Super Brain present a bold new understanding of our genes and how simple changes in lifestyle can boost genetic activity. The leap into "radical well-being" is a promise waiting to be fulfilled"--
The Tangled Tree
A Radical New History of Life
Hardcover ISBN: 1476776628
Nonpareil science writer David Quammen explains how recent discoveries in molecular biology can change our understanding of evolution and life’s history, with powerful implications for human health and even our own human nature. The Tangled Tree features an eight-page insert with black and white art throughout. In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT. In The Tangled Tree David Quammen, “one of that rare breed of science journalists who blends exploration with a talent for synthesis and storytelling” (Nature), chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. “Quammen is no ordinary writer. He is simply astonishing, one of that rare class of writer gifted with verve, ingenuity, humor, guts, and great heart” (Elle). Now, in The Tangled Tree, he explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life—including where we humans fit upon it. Thanks to new technologies such as CRISPR, we now have the ability to alter even our genetic composition—through sideways insertions, as nature has long been doing. The Tangled Tree is a brilliant guide to our transformed understanding of evolution, of life’s history, and of our own human nature.
A Life Decoded
My Genome : My Life
Paperback ISBN: 0143114182
A leading genomic research scientist traces his lackluster education and military service in Vietnam before discovering his interest in scientific pursuits, his early achievements at the National Institutes of Health, and his sequencing of the first genome prior to the more expensive ventures of the Human Genome Project. Reprint.
Who We Are and How We Got Here
Ancient DNA and the New Science of the Human Past
Hardcover ISBN: 110187032x
A groundbreaking book about how technological advances in genomics and the extraction of ancient DNA have profoundly changed our understanding of human prehistory while resolving many long-standing controversies. Massive technological innovations now allow scientists to extract and analyze ancient DNA as never before, and it has become clear—in part from David Reich's own contributions to the field—that genomics is as important a means of understanding the human past as archeology, linguistics, and the written word. Now, in Who We Are and How We Got Here, Reich describes with unprecedented clarity just how the human genome provides not only all the information that a fertilized human egg needs to develop but also contains within it the history of our species. He delineates how the Genomic Revolution and ancient DNA are transforming our understanding of our own lineage as modern humans; how genomics deconstructs the idea that there are no biologically meaningful differences among human populations (though without adherence to pernicious racist hierarchies); and how DNA studies reveal the deep history of human inequality—among different populations, between the sexes, and among individuals within a population.
The God Gene
How Faith Is Hardwired Into Our Genes
Paperback ISBN: 0385720319
A noted geneticist and author of The Science of Desire offers a provocative argument that humans are genetically predisposed toward religious faith, explaining why spiritual belief provides an evolutionary advantage and revealing, through an analysis of the DNA makeup of people of various ages and backgrounds, how to identify a so-called God gene. Reprint. 25,000 first printing.