Pharmazieunternehmen verwenden zwar immer mehr Mittel, Zeit und Personal auf Forschung und Entwicklung, jedoch sinkt die Zahl der j hrlich neu zugelassenen Medikamente weiter ab. Dieses Buch zeigt Wege auf, die zu neuen Wirkstoffgruppen f hren k nnen, wobei die Betonung hier eher auf einem breiten berblick, als auf einer detaillierten Besprechung einzelner Methoden liegt. Ausf hrlich analysiert werden die Ver nderungen, die sich gegenw rtig in der pharmazeutischen Forschung und Entwicklung manifestieren. (06/98)

Examines the chromatographic and nonchromatographic methods available to identify, measure, and screen for nonmedical drug use, highlighting the latest technologies in immunochemical analysis, biosensors, thinlayer gas chromatography, high-performance liquid chromatography, and capillary electrophoresis. A comprehensive alphabetic listing of over 400 controlled-use drugs is provided.

This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Drug discovery strategies for both pharmaceutical and agrochemical applications are at a stage of rapid development. More than 30 % of sales of drugs for human consumption worldwide are of plant origin. This unique book covers the present status and future potential of natural products in drug discovery. It provides the reader with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods. Because the renewed interest in the use of natural sources in drug discovery is an important supplement to combinatorial and parallel synthesis approaches, this book is timely and will have a great scientific impact.

Garlic has today become the focus of modern medical research. Recognized for thousands of years for its amazing curative powers, this bulb is today not only known for its potent bouquet but is drawing the attention of the scientific world as a potential antibiotic, anti-cancer, antioxidant, anti-aging, anti-inflammatory...the list goes on and on. C. Gary Hullquist, M.D. began studying natural remedies long before graduating from Loma Linda University School of Medicine. His fascination with healing foods, from the clinical perspective of over twenty years as a practicing physician and lifelong vegetarian, has taken him from Appalachia to Africa in search of Nature's perfect prescription.

This handbook is filled with over 50 illustrations and descriptions of approximately 250 plants which are used for herbal medicine. It includes information on medicinal plants ranging from Abies spectabilis to Zizyphus vulgaris. The purpose of this handbook is to make available a reference for easy, accurate identification of these herbs. Derived from India, "Ayurveda" is the foundation stone of their ancient medical science. Approximately 80 percent of the population of India and other countries in the East continue to utilize this system of medicinal treatment. It is believed that the key to successful medication is the use of the correct herb. This is an indispensable resource for all physicians, pharmacists, drug collectors, and those interested in the healing arts.

This volume consists of a selection of English translations from the extensive writings of Dr. Francisco Hern ndez (1515-87). Celebrated in his own day as one of Spain's leading physicians and naturalists, he is now best remembered for his monumental work on the native plants and materia medica of central Mexico.

Sent to New Spain in 1570 by King Philip II to research and describe the natural history of the region, to assess the medical usefulness of the natural resources, and to gather ethnographic materials for an anthropological history, Hern ndez was the first trained scientist to undertake scientific work in the New World. For seven years he gathered information throughout the Valley of Mexico, learning Nahuatl, recording local medical customs, studying indigenous medicines, and writing down all his observations. The result was The Natural History of New Spain, written in Latin, which consisted of six folio volumes filled with descriptions of over 3,000 plants previously unknown in Europe (along with descriptions of a much smaller number of animals and minerals) and ten folio volumes of paintings by Mexican artists illustrating the plants and animals he described.

Hern ndez died before he could publish his Natural History, and the materials were placed in the Escorial, where they were extensively consulted, copied, abstracted, and translated by generations of scientists, medical specialists, and natural philosophers before they were destroyed by fire in 1671. Hern ndez's work was still regarded as authoritative on a number of New World botanical topics as late as the nineteenth century, and his writings remain in use in popular form in Mexico today.

Only a tiny fragment of the Natural History has previously appeared in English. The selections in this volume are designed to reflect the historical patterns of dissemination of the work of Hern ndez, giving modern readers a sense of which portions of his vast corpus entered scientific discourse and spread across two continents in the seventeenth and eighteenth centuries.

This book was tbe result of a symposium beld at tbe American Cbernical Society meeting in Miami Beacb, Florida, September 10-15, 1989. The symposium was jointly sponsored by Tbe Society for Economfc Botany and tbe American Cbernical Society Food and Natural Product sub division. Tbere were five speakers. During tbe social sessions (mostly over drinks in abotel room), it became obvious tbat, regardless of tbe discipline, we were all speaking tbe same language. Yet, prior to tbe symposium, only a few of tbe participants knew one anotber. We decided to expand tbe symposium into a book. The book would, we boped, accomplish for otbers wbat we bad discovered in ourselves. That is, the field of Natural Products is broad, but similar in techniques and approach, ancient but modern, and bas been and continues to be extremely valuable to humankind. We wanted the book to serve as an introductory text for courses and as a reference work for the future. We also determined to include the structure of every chemical in the chapter where it was mentioned so the reader would not have to find the structure somewhere else or to try and deduce the structure from the chemical name. Little did we know what an undertaking these goals would be or the time this would take.

This book was tbe result of a symposium beld at tbe American Cbernical Society meeting in Miami Beacb, Florida, September 10-15, 1989. The symposium was jointly sponsored by Tbe Society for Economfc Botany and tbe American Cbernical Society Food and Natural Product sub division. Tbere were five speakers. During tbe social sessions (mostly over drinks in abotel room), it became obvious tbat, regardless of tbe discipline, we were all speaking tbe same language. Yet, prior to tbe symposium, only a few of tbe participants knew one anotber. We decided to expand tbe symposium into a book. The book would, we boped, accomplish for otbers wbat we bad discovered in ourselves. That is, the field of Natural Products is broad, but similar in techniques and approach, ancient but modern, and bas been and continues to be extremely valuable to humankind. We wanted the book to serve as an introductory text for courses and as a reference work for the future. We also determined to include the structure of every chemical in the chapter where it was mentioned so the reader would not have to find the structure somewhere else or to try and deduce the structure from the chemical name. Little did we know what an undertaking these goals would be or the time this would take.