An exploration of the chemical, biological, psychological, and experiential dimensions of ayahuasca- Details the scientific discovery of ayahuasca's sophisticated psychoactive delivery system in the brain and body and its potential applications in medicine and psychology - Includes contributions from Dennis J. McKenna, Ph.D., J. C. Callaway, Ph.D., and Charles S. Grob, M.D., on the ethnopharmacology, psychology, phytochemistry, and neuropharmacology of ayahuasca - Provides 24 firsthand accounts of ayahuasca experiences and resulting life changes Widely recognized by anthropologists as the most powerful and widespread shamanic hallucinogen, ayahuasca has been used by native Indian and mestizo shamans in Peru, Colombia, and Ecuador for healing and divination for thousands of years. Made from the Amazonian vine Banisteriopsis caapi and the DMT-laden leaf of Psychotria viridis, ayahuasca is regarded as the embodiment of intelligent plant beings who can offer spiritual teachings and healing knowledge to those who respectfully engage with them. Many Western-trained physicians and psychologists now acknowledge that ayahuasca allows access to spiritual dimensions of consciousness, otherworldly realms and beings, and visionary experiences indistinguishable from classic religious mysticism. With contributions from leading psychoactive scholars Dennis J. McKenna, Ph.D., Charles S. Grob, M.D., and J. C. Calloway, Ph.D., on the ethnopharmacology, psychology, phytochemistry, and neuropharmacology of ayahuasca, Ralph Metzner provides a comprehensive exploration of the chemical, biological, psychological, and experiential dimensions of this Amazonian hallucinogen. He includes more than 20 firsthand accounts from people who have participated in ayahuasca rituals and experienced major life changes as a result. He details the scientific discovery of ayahuasca's sophisticated psychoactive delivery system in the brain and body as well as the deep psychological impact of this potent entheogen. He concludes with his own findings on ayahuasca, including its applications in medicine and psychology, and compares the worldview revealed by ayahuasca visions to that of modern cultures.
An exploration of the personal and spiritual truths revealed through LSD- Reveals that LSD visions weave an ongoing story from trip to trip - Shows that trips progress through three stages: personal issues and pre-birth consciousness, ego-loss, and on to the sacred - Explores psychedelic use throughout history, including the mass hallucinations common in the Middle Ages and the early therapeutic use of LSD Toward the end of his fifties, Christopher Gray took, for the first time in years, a 100-microgram acid trip. So extraordinary, and to his surprise so enjoyable, were the effects that he began to take the same dose in the same way--quietly and on his own--once every two to three weeks. In The Acid Diaries, Gray details his experimentation with LSD over a period of three years and shares the startling realization that his visions were weaving an ongoing story from trip to trip, revealing an underlying reality of personal and spiritual truths. Following the theories of Stanislav Grof and offering quotes from others' experiences that parallel his own--including those of Aldous Huxley, Albert Hofmann, and Gordon Wasson--he shows that trips progress through three stages: the first dealing with personal issues and pre-birth consciousness; the second with ego-loss, often with supernatural overtones; and the third with sacred, spiritual, and even apocalyptic themes. Pairing his experiences with an exploration of psychedelic use throughout history, including the ergot-spawned mass hallucinations that were common through the Middle Ages and the early use of LSD for therapeutic purposes, Gray offers readers a greater understanding and appreciation for the potential value of LSD not merely for transpersonal growth but also for spiritual development.
A national study indicated that 11 percent of U.S. children and teens were diagnosed with attention deficit/hyperactivity disorder (ADHD) in 2011--a figure 43 percent higher than in 2003. The incidence of ADHD diagnoses among females has also increased significantly. For the millions of Americans of all ages who are diagnosed with ADHD, the proper treatment of this disorder is critically important. ADHD Medications: History, Science, and Issues provides readers with the complete story of ADHD drugs. The book discusses the pharmacological basis of the effects of these powerful drugs; examines the myriad social dimensions of the use, misuse, and abuse of these substances; and identifies the range of issues that affect the recognition, diagnosis, and treatment of ADHD.
After an introductory case study of an individual with ADHD and this individual's problems and successes with ADHD medicines, this new book in the Story of a Drug series provides an overview of ADHD and its various symptoms, as well as the causes, prevalence, and diagnosis of ADHD. Various treatment approaches--including information about the many medications used--are discussed in detail, as well as other substances and alternative ways used to treat individuals with ADHD. Readers will also gain an understanding of neurotransmission and the specific mechanism of action of ADHD medications; the effects and applications of these drugs, plus their associated risks, misuse, and abuse; as well as related policy issues, with special focus on the controversial issues regarding ADHD drug scheduling (categorization).
Inducing highs of excitement, anger, and terror, adrenaline fuels the extremes of human experience. A rush empowers superhuman feats in emergencies. Risk-taking junkies seek to replicate this feeling in dangerous recreations. And a surge may literally scare us to death. Adrenaline brings us up to speed on the fascinating molecule that drives some of our most potent experiences.
Adrenaline was discovered in 1894 and quickly made its way out of the lab into clinics around the world. In this engrossing account, Brian Hoffman examines adrenaline in all its capacities, from a vital regulator of physiological functions to the subject of Nobel Prize-winning breakthroughs. Because its biochemical pathways are prototypical, adrenaline has had widespread application in hormone research leading to the development of powerful new drugs. Hoffman introduces the scientists to whom we owe our understanding, tracing the paths of their discoveries and aspirations and allowing us to appreciate the crucial role adrenaline has played in pushing modern medicine forward.
Hoffman also investigates the vivid, at times lurid, place adrenaline occupies in the popular imagination, where accounts of its life-giving and lethal properties often leave the realm of fact. Famous as the catalyst of the "fight or flight" response, adrenaline has also received forensic attention as a perfect poison, untraceable in the bloodstream--and rumors persist of its power to revive the dead. True to the spirit of its topic, Adrenaline is a stimulating journey that reveals the truth behind adrenaline's scientific importance and enduring popular appeal.
Antipsychotics are unique drugs with the ability to alter how people think and communicate. As a result, physicians must weigh a range of implications when prescribing antipsychotics. Antipsychotics: History, Science, and Issues offers a robust explanation of antipsychotic medications that covers the historical, ethical, medical, legal, and scientific dimensions of antipsychotics.
The chapters explore topics ranging from the science of how examples of this class of drug actually work in the body to the social and legal implications of antipsychotics, making this subject understandable and relatable for lay readers who are not mental health practitioners. Readers will learn why prescribing antipsychotics is often a difficult decision due to the inherent risks of giving these medications to different types of patients and appreciate how mental health laws impact psychiatrists' prescribing practices.
Robert Kanigel takes us into the heady world of a remarkable group of scientists working at the National Institutes of Health and the Johns Hopkins University: a dynasty of American researchers who for over forty years have made Nobel Prize- and Lasker Award-winning breakthroughs in biomedical science.
This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic involuntary nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form.; This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.
Biochemical pharmacology is an emerging field which applies the concepts of biochemistry for producing better quality and effective drugs. This book brings forth some ground-breaking research from across the globe which will contribute to further the scope of this field. The theories, models and techniques discussed in this book will prove beneficial to students, chemists, researchers and professionals. It aims to facilitate the growth of this discipline and set ground for new research.
With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.
- Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods
- Chapters organized according to the sequential nature of the drug development process
- Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods
- Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity
- With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.
We take our medicines on faith. We assume our doctors are well-informed, our drug companies scrupulous, our FDA diligent--and our medications safe. All too often we're wrong. Just how wrong is documented in this critically acclaimed portrait of the international pharmaceutical industry by one of our most highly respected investigative journalists.According to the Journal of the American Medical Association (JAMA), adverse drug reactions are the fourth leading cause of death in America. Reactions to prescription and over-the-counter medications kill far more people annually than all illegal drug use combined. Stephen Fried's wife took a pill for a minor infection--and ended up in the emergency room. Some drug reactions go away in a few hours or days. Diane's did not. This emotionally wrenching experience launched Fried into a five-year examination of the entire pharmaceutical industry, the most profitable legal business in the world. Rigorously documented, Bitter Pills is a full-scale portrait of pill making and pill taking in America today, presented through the powerful human drama of doctors, patients, drug companies, the FDA, and government regulators as they war for control of our medicine cabinets.