--John M. Barry, New York Times bestselling author of The Great Influenza The epic and controversial story of a major breakthrough in cell biology that led to the conquest of rubella and other devastating diseases. Until the late 1960s, tens of thousands of American children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant; there was no vaccine and little understanding of how the disease devastated fetuses. In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman's masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who "owns" research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus imperiling pregnant women on the rise today, no medical story could have more human drama, impact, or urgency today than The Vaccine Race.
At a time of increased interest and renewed shock over the Tuskegee syphilis experiments, Acres of Skin sheds light on yet another dark episode of American medical history. In this disturbing expose, Allen M. Hornblum tells the story of Philadelphia's Holmesburg Prison.
The `effectiveness revolution' both in research and clinical practice, has tested available methods for health services research to the extreme. How far can observational methods, routine data and qualitative methods be used in health care evaluation? What cost and outcome measures are appropriate, and how should data be gathered?
With the support of over two million pounds from the British Health Technology Assessment Research Programme, the research project for this Handbook has led to both a synthesis of all of the existing knowledge in these areas and an agenda for future debate and research.
The chapters and their authors have been selected through a careful process of peer review and provide a coher
Bone marrow located in the heads of long bones can be termed as a manufacturing center of red blood cells and lymphocytes as it produces billions of cells per day depending upon the requirement of the body. Bone marrow transplant is regarded as one of the most popular methods for treating blood cancer. Stem cells are generally found in embryos. These cells have a remarkable tendency to transform themselves into different body cells with the help of stem cell engineering techniques. Due to their regenerative potential they have the capability to treat diseases like heart problems, diabetes, etc. This book presents the complex subjects of bone marrow and stem cell research in the most comprehensible and easy to understand language. It attempts to understand the multiple branches that fall under the discipline of bone marrow and stem cells, and how such concepts have practical applications. The various studies that are constantly contributing towards the evolution of these fields are examined in detail. It will help the readers in keeping pace with the rapid changes in this field.
Medicine as a field of science refers to the diagnosis, treatment, and prevention of varied disorders and diseases. It is a complex study of drugs that are used to treat lethal illnesses like cancer, tumor or non-lethal diseases like common cold, polio, etc. The aim of this text is to present researches that have transformed this discipline and aided its advancement. It will prove helpful to the students by providing information about the various advances and concepts related to the subjects. Different approaches, evaluations, methodologies and advanced studies on medicine have been included in it.
This book presents a collection of invited contributions, each reflecting an area of biomedicine in which simulation techniques have been successfully applied. Thus, it provides a state-of-the-art survey of simulation techniques in a variety of biomedical applications. Chapter one presents the conceptual framework for advanced simulations such as parallel processing in biological systems. Chapter two focuses on structured biological modeling based on the bond graph method. This is followed by an up-to-date account of advanced simulation of a variety of sophisticated biomedical processes. The authors provide many insights into how computer simulation techniques and tools can be applied to research problems in biomedicine. The idea for this book arose out of the daily work by experts in their field and reflects developing areas. Therefore, I think the material is timely and hope that the work described will be an encouragement for others. It is the objective of this book to present advanced simulation techniques in biomedicine and outline current research, as well as to point out open problems, in this dynamic field. Finally, I wish to express my thanks to those colleagues who have made this book possible with their contributions.
First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology.Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2010 impact factor is1.683