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Aging Biology
Evolutionary Biology of Aging
Evolutionary Biology of Aging
Paperback      ISBN: 0195095308

This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful
determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for
seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the
central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Free Radicals in the Brain: Aging, Neurological and Mental Disorders
Free Radicals in the Brain
Aging, Neurological and Mental Disorders
Paperback      ISBN: 3642776116

Free radicals appear to play a mojor role in many neurological (and non- neurological) dieseases. Both acute and degenerative disorders are thought to involve free radicals reactions in tissue injury (for a list see this book page 18). This issue is very important for basic science and for therapeuthic approach as well. In order to review and discuss the place of free radicals in psychiatry and neurology, a joint meeting was initiated by the World Health Organization and the Fondation Ipsen in Paris on June 17-18,1991. This book contains the papers presented during this meeting. Although the papers included in this volume have been produced in the framework of WHO/Fondation Ipsen review of knowledge about free radicals and brain disorders, they express the views of the individual authors rather than a consensus of the participants at the meeting. They do not necessarily represent the decision or stated policy of the World Health Organiszation or the Fondation Ipsen. The editors wish to express their appreciation to Mrs Mervaillie for the organization of the meeting and Mrs M.-L. Gage for her editorial assis- tance. L. Packer, L. Prilipko, Y Christen Contents Free Radical Scavengers and Antioxidants in Prophylaxy and Treatment of Brain Diseases L. Packer ........................................... 1 Reactive Oxygen Species and the Central Nervous System B. Halliwell .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 . . . . . . . . .

The Happiness Curve: Why Life Gets Better After 50
The Happiness Curve
Why Life Gets Better After 50
Paperback      ISBN: 1250080916

In this warm, wise, and witty overview, Jonathan Rauch combines evidence and experience to show his fellow adults that the best is yet to come." --Steven Pinker, bestselling author of Enlightenment Now

This book will change your life by showing you how life changes.

Why does happiness get harder in your 40s? Why do you feel in a slump when you're successful? Where does this malaise come from? And, most importantly, will it ever end?

Drawing on cutting-edge research, award-winning journalist Jonathan Rauch answers all these questions. He shows that from our 20s into our 40s, happiness follows a U-shaped trajectory, a "happiness curve," declining from the optimism of youth into what's often a long, low slump in middle age, before starting to rise again in our 50s.

This isn't a midlife crisis, though. Rauch reveals that this slump is instead a natural stage of life--and an essential one. By shifting priorities away from competition and toward compassion, it equips you with new tools for wisdom and gratitude to win the third period of life.

And Rauch can testify to this personally because it was his own slump, despite acclaim as a journalist and commentator that compelled him to investigate the happiness curve. His own story and the stories of many others from all walks of life--from a steelworker and a limo driver to a telecoms executive and a philanthropist--show how the ordeal of midlife malaise reboots our values and even our brains for a rebirth of gratitude.

Full of insights and data and featuring many ways to endure the slump and avoid its perils and traps, The Happiness Curve doesn't just show you the dark forest of midlife, it helps you find a path through the trees. It also demonstrates how we can--and why we must--do more to help each other through the woods. Midlife is a journey we mustn't walk alone.

Human Longevity from Antiquity to the Modern Lab: A Selected, Annotated Bibliography
Human Longevity from Antiquity to the Modern Lab
A Selected, Annotated Bibliography
Hardcover      ISBN: 0313253714

Product information not available.

Interrelationship Among Aging, Cancer and Differentiation: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Hel
Interrelationship Among Aging, Cancer and Differentiation
Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Hel
Hardcover      ISBN: 9027721173

In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled -Carcl- nogenesls: Fundamental Mechanisms and Environmental Effects-. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo- gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.

The Living End: The New Sciences of Death, Ageing and Immortality
The Living End
The New Sciences of Death, Ageing and Immortality
1st Edition    Hardcover      ISBN: 0230517579

The decline of infections, starvation, heart attack, and stroke has allowed people to reach extreme old age--and ushered in disability, dementia, and degenerative disease, with profound consequences for the self and society. In chapters echoing Dante's nine circles of hell, Dr. Guy Brown explores these vital issues at various levels, from the cell, to the whole body, to society and how all this new medical technology affects the meaning of death. He tracks the seismic shifts in the causes and character of death that are rocking medicine and reveals how technological innovations, such as cloning and electronic interfaces, hint at new modes of "survival" after death.

The Longevity Paradox: How to Die Young at a Ripe Old Age
The Longevity Paradox
How to Die Young at a Ripe Old Age
Hardcover      ISBN: 0062843397

From the author of the New York Times bestseller The Plant Paradox comes a groundbreaking plan for living a long, healthy, happy life.

From the moment we are born, our cells begin to age. But aging does not have to mean decline. World-renowned surgeon Dr. Steven Gundry has been treating mature patients for most of his career. He knows that everyone thinks they want to live forever, until they hit middle age and witness the suffering of their parents and even their peers. So how do we solve the paradox of wanting to live to a ripe old age--but enjoy the benefits of youth?

This groundbreaking book holds the answer. Working with thousands of patients, Dr. Gundry has discovered that the "diseases of aging" we most fear are not simply a function of age; rather, they are a byproduct of the way we have lived over the decades. In The Longevity Paradox, he maps out a new approach to aging well--one that is based on supporting the health of the "oldest" parts of us: the microorganisms that live within our bodies.

Our gut bugs--the bacteria that make up the microbiome--largely determine our health over the years. From diseases like cancer and Alzheimer's to common ailments like arthritis to our weight and the appearance of our skin, these bugs are in the driver's seat, controlling our quality of life as we age.

The good news is, it's never too late to support these microbes and give them what they need to help them--and you--thrive. In The Longevity Paradox, Dr. Gundry outlines a nutrition and lifestyle plan to support gut health and live well for decades to come. A progressive take on the new science of aging, The Longevity Paradox offers an action plan to prevent and reverse disease as well as simple hacks to help anyone look and feel younger and more vital.

A Means to an End: The Biological Basis of Aging and Death
A Means to an End
The Biological Basis of Aging and Death
Paperback      ISBN: 0195153758

Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science
fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.
With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of
aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric
intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of
gene therapy on senescence, and what we might learn about aging from experiments in cloning.
This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.

Model Systems of Development and Aging of the Nervous System
Model Systems of Development and Aging of the Nervous System
Hardcover      ISBN: 0898388384

The last decade has generated a multitude of studies using in vitro model systems to explore growth and differentiation of the nervous system. Although the findings have been exciting and have revealed unique properties of neural cells, considerable concern continues to be expressed regarding the significance of in vitro findings in terms of their applicability to in vivo biological events. To examine this issue further, a group of scientists pre- sented and discussed their findings at a conference sponsored by the Institute of Developmental Neuroscience and Aging held in Crete, Greece, 26-29 May 1985. The conference was cosponsored by the University of Crete and was generously supported by the Ministry of Research and Technology of Greece, Tourism Organization of Greece, and also Sandoz and FIDIA. The Directors of the Institute of Developmental Neuroscience and Aging are indebted to these Institutions for their support. For the success of this conference, the Directors owe much to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who spent countless hours in making arrangements so that the participants would have not only a scientific, but also a unique cultural, experience. Several chapters of this book focus on the complex phenomena of neurogenesis and gliogenesis, and the modulation of neuronal differentiation. The concept that neuronal differentiation has both genetic and epigenetic components is documented by elegant studies using both in vitro cultured cells and neurons transplanted in vivo.

Model Systems of Development and Aging of the Nervous System
Model Systems of Development and Aging of the Nervous System
Paperback      ISBN: 1461292123

The last decade has generated a multitude of studies using in vitro model systems to explore growth and differentiation of the nervous system. Although the findings have been exciting and have revealed unique properties of neural cells, considerable concern continues to be expressed regarding the significance of in vitro findings in terms of their applicability to in vivo biological events. To examine this issue further, a group of scientists pre- sented and discussed their findings at a conference sponsored by the Institute of Developmental Neuroscience and Aging held in Crete, Greece, 26-29 May 1985. The conference was cosponsored by the University of Crete and was generously supported by the Ministry of Research and Technology of Greece, Tourism Organization of Greece, and also Sandoz and FIDIA. The Directors of the Institute of Developmental Neuroscience and Aging are indebted to these Institutions for their support. For the success of this conference, the Directors owe much to Drs. Eleni Fleischer-Lambropoulos and Yiannis Tsouderos, who spent countless hours in making arrangements so that the participants would have not only a scientific, but also a unique cultural, experience. Several chapters of this book focus on the complex phenomena of neurogenesis and gliogenesis, and the modulation of neuronal differentiation. The concept that neuronal differentiation has both genetic and epigenetic components is documented by elegant studies using both in vitro cultured cells and neurons transplanted in vivo.