Genetic Code
Genetics and Public Health in the 21st Century: Using Genetic Information to Improve Health and Prevent Disease
Genetics and Public Health in the 21st Century
Using Genetic Information to Improve Health and Prevent Disease
Hardcover      ISBN: 0195128303

With the accelerating discovery of human genes, public health professionals are increasingly confronted with a large body of scientific information that will guide public health action. Because the broad mission of public health is to fulfill society's interest in assuring conditions in which people can be healthy, the integration of new genetic information in public health research, policy, and program development is unavoidable. Public health leadership is urgently needed to use genetic information to improve health and prevent disease, and to address ethical, legal and social issues resulting from inappropriate use of such information. In the not too-distant future, disease prevention and health promotion programs will routinely consider whether or not to use genetic information to help target behavioral, medical or environmental intervention activities in order to maximize benefit and minimize costs and harm to individuals. In anticipation of the expected growth at the interface of genetics and public health, this book delineates a framework for the integration of advances in human genetics into public health practice. It provides a comprehensive review of public health genetics, including chapters on important general issues such as newborn and other genetic screening, the delivery of genetic services, and the ethical, legal and social implications of the use of genetics within public health. It also reviews relevant clinical topics, the historical background, cross-cultural aspects, and communication issues. Contributors come from a wide range of fields including epidemiology, biostatistics, health policy and management, health services research, behavioral and social sciences, ethics, law, health economics, and laboratory sciences.

Genomes
Genomes
Hardcover      ISBN: 0306463601

This volume brings together the disciplines of plant and animal genome research, and serves as an opportunity for scientists from both fields to compare results, problems and prospects.

Genomic Imprinting: Methods and Protocols
Genomic Imprinting
Methods and Protocols
Hardcover      ISBN: 089603741x

Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.

Genomics and Proteomics: Functional and Computational Aspects
Genomics and Proteomics
Functional and Computational Aspects
Paperback      ISBN: 1475781741

Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms'geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.

High Performance Computational Methods for Biological Sequence Analysis
High Performance Computational Methods for Biological Sequence Analysis
Hardcover      ISBN: 079239724x
High Performance Computational Methods for Biological Sequence Analysis presents biological sequence analysis using an interdisciplinary approach that integrates biological, mathematical and computational concepts. These concepts are presented so that computer scientists and biomedical scientists can obtain the necessary background for developing better algorithms and applying parallel computational methods. This book will enable both groups to develop the depth of knowledge needed to work in this interdisciplinary field.
This work focuses on high performance computational approaches that are used to perform computationally intensive biological sequence analysis tasks: pairwise sequence comparison, multiple sequence alignment, and sequence similarity searching in large databases. These computational methods are becoming increasingly important to the molecular biology community allowing researchers to explore the increasingly large amounts of sequence data generated by the Human Genome Project and other related biological projects. The approaches presented by the authors are state-of-the-art and show how to reduce analysis times significantly, sometimes from days to minutes.
High Performance Computational Methods for Biological Sequence Analysis is tremendously important to biomedical science students and researchers who are interested in applying sequence analyses to their studies, and to computational science students and researchers who are interested in applying new computational approaches to biological sequence analyses.
High Performance Computational Methods for Biological Sequence Analysis
High Performance Computational Methods for Biological Sequence Analysis
Paperback      ISBN: 1461286026
High Performance Computational Methods for Biological Sequence Analysis presents biological sequence analysis using an interdisciplinary approach that integrates biological, mathematical and computational concepts. These concepts are presented so that computer scientists and biomedical scientists can obtain the necessary background for developing better algorithms and applying parallel computational methods. This book will enable both groups to develop the depth of knowledge needed to work in this interdisciplinary field.
This work focuses on high performance computational approaches that are used to perform computationally intensive biological sequence analysis tasks: pairwise sequence comparison, multiple sequence alignment, and sequence similarity searching in large databases. These computational methods are becoming increasingly important to the molecular biology community allowing researchers to explore the increasingly large amounts of sequence data generated by the Human Genome Project and other related biological projects. The approaches presented by the authors are state-of-the-art and show how to reduce analysis times significantly, sometimes from days to minutes.
High Performance Computational Methods for Biological Sequence Analysis is tremendously important to biomedical science students and researchers who are interested in applying sequence analyses to their studies, and to computational science students and researchers who are interested in applying new computational approaches to biological sequence analyses.
The Human Genome Project and the Future of Health Care
The Human Genome Project and the Future of Health Care
Hardcover      ISBN: 0253332133

"The volume deserves our serious attention. The authors have provided us an invaluable primer about the HGP and its implications for the future of American health care." --Jurimetrics

"This book does make a real contribution . . . in explaining why the genetics
revolution holds so much promise and why it is so difficult to bring that promise to fruition." --The Journal of Legal Medicine

". . . marked by a forward-looking, analytically and empirically grounded thematic coherence. The editors' carefully crafted template and contributions successfully focus and organize the material." --Annals of Internal Medicine

"Excellent" --Canadian Medical Association Journal

"The editors have done a very good job integrating the contents into a very useful and readable information source." --Choice

" . . . this highly focused book is a well-written, thoughtful, and insightful consideration of the HGP and is valuable reading for anyone concerned with the future of our country's medical infrastructure." --Science Books & Films (**Highly recommended)

"A distinguished group of scientists, lawyers, and scholars have written a coherent, readable account of the legal, medical, ethical, and policy issues many (if not all) of us will be wrestling with on both a personal and a public level, as a result of current genetic research." --Library Journal

"Each of the contributors is a distinguished authority on the topic. Ethicists, especially, will find well-developed presentation of issues, with exposition of the differing ethical assumptions in tension in the society debate." --Doody's Health Sciences Book Review Home Page


How will the science of gene mapping and gene manipulation affect health care? Leading scholars explore the clinical, ethical, legal, and policy implications of the Human Genome Project for the forms of health care, who delivers it, who receives it, and who pays for it.

Introduction to Bioinformatics: A Theoretical and Practical Approach
Introduction to Bioinformatics
A Theoretical and Practical Approach
Hardcover      ISBN: 1588290646

to Bioinformatics A Theoretical and Practical Approach Edited by Stephen A. Krawetz, PhD Wayne State University School of Medicine, Detroit MI and David D. Womble, PhD Wayne State University School of Medicine, Detroit, MI Springer Science+ Business Media, LLC (c) 2003 Springer Science+Business Media New York Originally published by Humana Press ne. in 2003 Softcover reprint of the hardcover 1 st edition 2003 humanapress.com Ali rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. Ali papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. This publication is printed on acid-free paper. G) ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Production Editor: Mark J. Breaugh. Cover design by Patricia F. Cleary and Paul A. Thiessen. Cover illustration by Paul A. Thiessen, chemicalgraphics.com.

Lamarck's Revenge: How Epigenetics Is Revolutionizing Our Understanding of Evolution's Past and Present
Lamarck's Revenge
How Epigenetics Is Revolutionizing Our Understanding of Evolution's Past and Present
Hardcover      ISBN: 1632866153

Epigenetics upends natural selection and genetic mutation as the sole engines of evolution, and offers startling insights into our future heritable traits.

In the 1700s, Jean-Baptiste Lamarck first described epigenetics to explain the inheritance of acquired characteristics; however, his theory was supplanted in the 1800s by Darwin's theory of evolution by natural selection through heritable genetic mutations. But natural selection could not adequately explain how rapidly species re-diversified and repopulated after mass extinctions. Now advances in the study of DNA and RNA have resurrected epigenetics, which can create radical physical and physiological changes in subsequent generations by the simple addition of a single small molecule, thus passing along a propensity for molecules to attach in the same places in the next generation.

Epigenetics is a complex process, but paleontologist and astrobiologist Peter Ward breaks it down for general readers, using the epigenetic paradigm to reexamine how the history of our species--from deep time to the outbreak of the Black Plague and into the present--has left its mark on our physiology, behavior, and intelligence. Most alarming are chapters about epigenetic changes we are undergoing now triggered by toxins, environmental pollutants, famine, poor nutrition, and overexposure to violence.

Lamarck's Revenge is an eye-opening and provocative exploration of how traits are inherited, and how outside influences drive what we pass along to our progeny.

A Life Decoded: My Genome---My Life
A Life Decoded
My Genome---My Life
Compact Disc      ISBN: 1400155711

Growing up in California, J. Craig Venter didn't appear to have much of a future. An unremarkable student, he nearly flunked out of high school. After being drafted into the army, he enlisted in the navy and went to Vietnam, where the life-and-death struggles he encountered as a medic piqued his interest in science and medicine. After pursuing his advanced degrees, Venter quickly established himself as a brilliant and outspoken scientist. In 1984, he joined the National Institutes of Health, where he introduced novel techniques for rapid gene discovery, and left in 1991 to form his own nonprofit genomics research center, where he sequenced the first genome in history in 1995. In 1998, he announced that he would successfully sequence the human genome years earlier and for far less money than the government-sponsored Human Genome Project would-a prediction that came to pass in 2001. A Life Decoded is the triumphant story of one of the most fascinating and controversial figures in science today. In this riveting and inspiring account, Venter tells of the unparalleled drama of the quest for the human genome, a tale that involves as much politics as science. He also reveals how he went on to be the first to read and interpret his own genome and what it will mean for all of us to do the same. He describes his recent sailing expedition to sequence microbial life in the ocean, as well as his groundbreaking attempt to create synthetic life. Here is one of the key scientific chronicles of our lifetime, as told by the man who beat the odds to make it happen.